The Promise of ESCAT: A New System for Evaluating Cancer Drug-Target Pairs

Gyawali B, Kesselheim AS - Nature Reviews Clinical Oncology

  • Regulation and Clinical Evidence

Summary:

The authors evaluate the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), praising it as a useful common language for classifying the evidence behind target-drug combinations in precision oncology, while identifying areas for improvement to increase its utility for clinical decision-making, trial planning, and reimbursement policy.

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Recent Work from PORTAL

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How Congress Can Fix Expert Advisory Committees

Daval CJR, Kesselheim AS - STAT

  • Regulation and Clinical Evidence
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International Regulatory Status and Reimbursement Recommendations of Haematological Malignancy Drugs Withdrawn from the FDA Accelerated Approval Pathway

Mulsant SS, Kesselheim AS, Naci H - Journal of Cancer Policy

  • Price, Value, and Access
  • Regulation and Clinical Evidence
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Politics and the Patient Encounter, in Dire Times

Avorn J - MedPage Today

  • Regulation and Clinical Evidence