The Most Transformative Drugs of the Past 25 Years: A Survey of Physicians

Approximately 180 expert physicians across 15 medical specialties used an iterative Delphi process to identify the most transformative drugs approved over the past 25 years, with effectiveness and superiority over existing alternatives emerging as the primary factors influencing their assessments. The authors argue that establishing consensus on what constitutes transformative drug innovation can better inform strategic and legislative efforts to catalyze pharmaceutical development.