Clinical Implementation of Multi-Cancer Early Detection Tests: Can We Find a Path Forward?

The authors discuss the growing momentum behind multi-cancer early detection (MCED) blood tests, including the Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage Act, which creates a pathway to Medicare coverage to accelerate access once clinical benefit is confirmed. They argue, however, that MCED tests should be evaluated using the same rigorous standards expected of cancer screening programs, including randomized trials assessing mortality outcomes, before widespread adoption.